| Entry |
|
|---|
| Name |
Torsemide (USP);
Torasemide (JAN/INN);
Demadex (TN);
Luprac (TN) |
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| Product |
|
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| Generic |
TORSEMIDE (A-S Medication Solutions), TORSEMIDE (A-S Medication Solutions), TORSEMIDE (American Health Packaging), TORSEMIDE (Aphena Pharma Solutions - Tennessee), TORSEMIDE (Aphena Pharma Solutions - Tennessee), TORSEMIDE (Aurobindo Pharma Limited), TORSEMIDE (AvKARE), TORSEMIDE (AvPAK), TORSEMIDE (Bryant Ranch Prepack), TORSEMIDE (Bryant Ranch Prepack), TORSEMIDE (Camber Pharmaceuticals), TORSEMIDE (Chartwell RX), TORSEMIDE (Direct_Rx), TORSEMIDE (Golden State Medical Supply), TORSEMIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), TORSEMIDE (Hikma Pharmaceuticals USA), TORSEMIDE (Major Pharmaceuticals), TORSEMIDE (NCS HealthCare of KY), TORSEMIDE (REMEDYREPACK), TORSEMIDE (Redpharm Drug), TORSEMIDE (Rising Health), TORSEMIDE (Teva Pharmaceuticals USA) |
|---|
| Formula |
C16H20N4O3S
|
|---|
| Exact mass |
348.1256
|
|---|
| Mol weight |
348.42
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01690 Sulfonamide diuretic
DG01747 Furosemide type diuretic
DG01748 Loop diuretic
DG01747 Furosemide type diuretic
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG01642 CYP2C9 substrate
|
|---|
| Remark |
| Therapeutic category: | 2139 |
| Product (DG00273): | D00382<JP/US> |
|
|---|
| Efficacy |
Diuretic, Na-K-Cl cotransporter inhibitor |
|---|
| Disease |
|
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| Comment |
loop diuretic
Sulfonamide derivative
|
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| Target |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP2C8 [HSA: 1558]
|
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| Interaction |
|
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| Structure map |
| map07017 | Sulfonamide derivatives - diuretics |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03C HIGH-CEILING DIURETICS
C03CA Sulfonamides, plain
C03CA04 Torasemide
D00382 Torsemide (USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Diuretics, Loop
Torsemide
D00382 Torsemide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
213 Diuretics
2139 Others
D00382 Torsemide (USP); Torasemide (JAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01690 Sulfonamide diuretic
DG01747 Furosemide type diuretic
DG00273 Torasemide
D00382 Torsemide
DG01748 Loop diuretic
DG01747 Furosemide type diuretic
DG00273 Torasemide
D00382 Torsemide
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00273 Torasemide
D00382 Torsemide
DG01642 CYP2C9 substrate
DG00273 Torasemide
D00382 Torsemide
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC12
SLC12A1 (NKCC2)
D00382 Torsemide (USP) <JP/US>
SLC12A2 (NKCC1)
D00382 Torsemide (USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00382
Drug groups [BR:br08330]
Cardiovascular agent
DG01690 Sulfonamide diuretic
DG01747 Furosemide type diuretic
DG00273 Torasemide
DG01748 Loop diuretic
DG01747 Furosemide type diuretic
DG00273 Torasemide
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00273 Torasemide
DG01642 CYP2C9 substrate
DG00273 Torasemide
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 24
1 C8y C 26.1216 -19.9949
2 C8y C 27.3390 -19.3074
3 S4a S 24.9155 -19.3074
4 C8x C 26.1156 -21.3989
5 N1b N 27.3974 -17.8975
6 C8x C 28.5510 -20.0066
7 N1b N 23.7036 -20.0066
8 O3c O 25.9060 -18.3054
9 O3c O 23.9135 -18.3054
10 N5x N 27.3274 -22.1097
11 C8y C 28.5393 -17.1867
12 C8x C 28.5451 -21.4106
13 C5a C 22.4919 -19.3132
14 C8x C 28.5393 -15.7884
15 C8x C 29.7453 -17.8916
16 N1b N 21.2800 -20.0123
17 O5a O 22.4860 -17.9149
18 C8y C 29.7453 -15.0952
19 C8x C 30.9571 -17.1926
20 C1c C 20.0799 -19.3191
21 C8x C 30.9571 -15.7943
22 C1a C 29.7453 -13.6969
23 C1a C 18.8681 -20.0182
24 C1a C 20.0740 -17.9208
BOND 25
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 2
8 3 9 2
9 4 10 1
10 5 11 1
11 6 12 1
12 7 13 1
13 11 14 1
14 11 15 2
15 13 16 1
16 13 17 2
17 14 18 2
18 15 19 1
19 16 20 1
20 18 21 1
21 18 22 1
22 20 23 1
23 20 24 1
24 10 12 2
25 19 21 2
|
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