KEGG   DRUG: Torsemide
Entry
D00382                      Drug                                   
Name
Torsemide (USP);
Torasemide (JAN/INN);
Demadex (TN);
Luprac (TN)
Product
  Generic
Formula
C16H20N4O3S
Exact mass
348.1256
Mol weight
348.42
Structure
Simcomp
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
  DG01747  Furosemide type diuretic
 DG01748  Loop diuretic
  DG01747  Furosemide type diuretic
Metabolizing enzyme substrate
 DG02918  CYP2C8 substrate
 DG01642  CYP2C9 substrate
Remark
Therapeutic category: 2139
ATC code: C03CA04
Chemical structure group: DG00273
Product (DG00273): D00382<JP/US>
Efficacy
Diuretic, Na-K-Cl cotransporter inhibitor
  Disease
Hypertension [DS:H01633]
Comment
loop diuretic
Sulfonamide derivative
Target
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425]
SLC12A2 (NKCC1) [HSA:6558] [KO:K10951]
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP2C8 [HSA:1558]
Interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA04 Torasemide
      D00382  Torsemide (USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Loop
   Torsemide
    D00382  Torsemide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2139  Others
     D00382  Torsemide (USP); Torasemide (JAN/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01690  Sulfonamide diuretic
   DG01747  Furosemide type diuretic
    DG00273  Torasemide
     D00382  Torsemide
  DG01748  Loop diuretic
   DG01747  Furosemide type diuretic
    DG00273  Torasemide
     D00382  Torsemide
 Metabolizing enzyme substrate
  DG02918  CYP2C8 substrate
   DG00273  Torasemide
    D00382  Torsemide
  DG01642  CYP2C9 substrate
   DG00273  Torasemide
    D00382  Torsemide
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1 (NKCC2)
     D00382  Torsemide (USP) <JP/US>
    SLC12A2 (NKCC1)
     D00382  Torsemide (USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00382
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01690  Sulfonamide diuretic
   DG01747  Furosemide type diuretic
    DG00273  Torasemide
  DG01748  Loop diuretic
   DG01747  Furosemide type diuretic
    DG00273  Torasemide
 Metabolizing enzyme substrate
  DG02918  CYP2C8 substrate
   DG00273  Torasemide
  DG01642  CYP2C9 substrate
   DG00273  Torasemide
Other DBs
CAS: 56211-40-6
PubChem: 7847448
ChEBI: 9637
LigandBox: D00382
NIKKAJI: J11.135J
KCF data

ATOM        24
            1   C8y C    26.1216  -19.9949
            2   C8y C    27.3390  -19.3074
            3   S4a S    24.9155  -19.3074
            4   C8x C    26.1156  -21.3989
            5   N1b N    27.3974  -17.8975
            6   C8x C    28.5510  -20.0066
            7   N1b N    23.7036  -20.0066
            8   O3c O    25.9060  -18.3054
            9   O3c O    23.9135  -18.3054
            10  N5x N    27.3274  -22.1097
            11  C8y C    28.5393  -17.1867
            12  C8x C    28.5451  -21.4106
            13  C5a C    22.4919  -19.3132
            14  C8x C    28.5393  -15.7884
            15  C8x C    29.7453  -17.8916
            16  N1b N    21.2800  -20.0123
            17  O5a O    22.4860  -17.9149
            18  C8y C    29.7453  -15.0952
            19  C8x C    30.9571  -17.1926
            20  C1c C    20.0799  -19.3191
            21  C8x C    30.9571  -15.7943
            22  C1a C    29.7453  -13.6969
            23  C1a C    18.8681  -20.0182
            24  C1a C    20.0740  -17.9208
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 2
            8     3   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13   11  14 1
            14   11  15 2
            15   13  16 1
            16   13  17 2
            17   14  18 2
            18   15  19 1
            19   16  20 1
            20   18  21 1
            21   18  22 1
            22   20  23 1
            23   20  24 1
            24   10  12 2
            25   19  21 2

» Japanese version   » Back

DBGET integrated database retrieval system